Fibronectin, integrins, and growth control

Mesoderm induction and the control of gastrulation in Xenopus laevis: the roles of fibronectin and integrins.

Exposure of isolated Xenopus animal pole ectoderm to the XTC mesoderm-inducing factor (XTC-MIF) causes the tissue to undergo gastrulation-like movements. In this paper, we take advantage of this observation to investigate the control of various aspects of gastrulation in Xenopus. Blastomeres derived from induced animal pole regions are able, like marginal zone cells, but unlike control animal p...

Fibronectin and integrins in cell adhesion and migration.

Introduction Fibronectin, other cell-adhesion molecules, and their integrin receptors appear to play important roles in cell migration during embryonic development, tumour-cell invasion and metastasis, and wound healing (reviewd in [ 11). Recent studies have defined critical peptide-recognition regions in fibronectin that are required for its interactions with cell-surface receptors. For exampl...

Mutual cross-talk between fibronectin integrins and the EGF receptor

Extension of the plasma membrane is one of the first steps in cell migration. Understanding how cells "choose" between various types of membrane protrusion enhances our knowledge of both normal and cancer cell physiology. The EGF receptor is a paradigm for understanding how transmembrane receptor tyrosine kinases regulate intracellular signaling following ligand stimulation. Evidence from the p...

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

Upon binding to the extracellular matrix protein, fibronectin, αV-class and α5β1 integrins trigger the recruitment of large protein assemblies and strengthen cell adhesion. Both integrin classes have been functionally specified, however their specific roles in immediate phases of cell attachment remain uncharacterized. Here, we quantify the adhesion of αV-class and/or α5β1 integrins expressing ...

Integrins in invasive growth.